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The investigators will conduct a randomized controlled trial comparing the use of nasal midazolam, using a Mucosal Atomization Devise, to rectal diazepam for the treatment of acute seizure activity in children under the age of 18 years with epilepsy in the community setting.
The intranasal midazolam group reported a median time to seizure cessation of 3 minutes. The rectal diazepam group was 1.3 minutes slower Valium 5mg high
with a median time to seizure cessation of 4.3 minutes (95% confidence interval [95% CI], 0.0–3.5 minutes; p=0.09).
Acorda Therapeutics recently stopped trials of Plumiaz (diazepam or valium) Nasal Spray.
Early research suggests that diazepam can be delivered to people with epilepsy via a nasal spray.
Intranasal Midazolam vs Rectal Diazepam in Acute Childhood Seizures Madhumita Bhattacharyya Valium 5mg high
MD, Veena Kalra, MD, and Sheffali Gulati, MD One hundred eighty-eight ...
Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized ... epilepsy; IN, intranasal ...
ObjectiveTo compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children
DZNS (Diazepam Nasal Spray) is being developed as a potential treatment of epilepsy and epileptic cluster seizures. DZNS has FDA Orphan Drug Status.
Read "Bioavailability of Intranasal vs. Rectal Diazepam, Epilepsy Research" on DeepDyve, the largest online rental service for scholarly research with thousands of ...
Therapeutic Intranasal Drug Delivery ... the time to control a seizure using IV diazepam was statistically and clinically significantly longer ...